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Benperidol for schizophrenia.

S Leucht1, B Hartung

  • 1Psychiatrische Klinik und Poliklinik der Technischen Universität München Klinikum rechts der Isar, Ismaningerstr. 22, München, Germany, D-81675. stefan.leucht@lrz.tu-muenchen.de

The Cochrane Database of Systematic Reviews
|March 1, 2002
PubMed
Summary
This summary is machine-generated.

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Limited research on benperidol, an antipsychotic drug, shows it may be less effective than perphenazine for schizophrenia. More studies are needed to determine its clinical effects and safety.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology
  • Evidence-Based Medicine

Background:

  • Benperidol is a high-potency butyrophenone antipsychotic with a long history of use.
  • Its D2 receptor blockade suggests a high risk of extrapyramidal side effects.
  • An unusual profile may offer benefits for specific schizophrenia subgroups.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of benperidol in treating schizophrenia and schizophrenia-like psychoses.
  • To synthesize evidence from randomized controlled trials.

Main Methods:

  • Comprehensive search of multiple databases and trial registers up to January 2001.
  • Inclusion of randomized controlled trials comparing benperidol with other treatments.
  • Data extraction and quality assessment by two independent reviewers, with exclusion of studies with >50% loss to follow-up.

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Main Results:

  • Only one unpublished, poorly randomized trial (N=40) was identified, comparing benperidol to perphenazine.
  • Benperidol appeared inferior to perphenazine for global state improvement (RR 8.0, 95% CI 2.1 to 30).
  • Poor reporting in the single study suggests potential overestimation of effects; other outcomes could not be assessed.

Conclusions:

  • Insufficient randomized trial data exists to definitively assess benperidol's clinical effects.
  • Further rigorous research is warranted to explore the potential of this antipsychotic compound.