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Updated: Feb 11, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Somatic immunoglobulin hypermutation

Marilyn Diaz1, Paolo Casali

  • 1Department of Immunology, Imm16, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. mdiaz@scripps.edu

Current Opinion in Immunology
|March 1, 2002
PubMed

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

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