Related Experiment Videos
Neonatal diffusion-weighted MR imaging: relation with histopathology or follow-up MR examination
A M Roelants-van Rijn1, P G Nikkels, F Groenendaal
1Department of Neonatology, University Medical Center, Utrecht, The Netherlands.
Neuropediatrics
|March 1, 2002
Summary
Neonatal diffusion-weighted imaging (DWI) shows more extensive brain injury than conventional MRI. Follow-up MRI in survivors revealed smaller cystic lesions than initially suggested by neonatal DWI findings.
Area of Science:
- Neonatal Neurology
- Neuroimaging
- Pediatric Radiology
Background:
- Diffusion-weighted imaging (DWI) is standard for adult stroke evaluation.
- Its utility in neonates requires further establishment.
Purpose of the Study:
- To compare neonatal DWI with histopathology in deceased neonates.
- To compare neonatal DWI with follow-up MRI in surviving neonates.
Main Methods:
- Two groups of neonates were studied.
- Group 1: Seven neonates who died underwent post-mortem examination.
- Group 2: Six surviving neonates had follow-up MRI at three months.
Main Results:
- Neonatal DWI revealed more extensive involvement than conventional MRI in most patients.
- In deceased neonates, DWI findings were less extensive than histopathology.
- In survivors, follow-up MRI showed less cystic evolution than predicted by neonatal DWI.
Conclusions:
- Neonatal DWI correlates well with cytotoxic edema and neuronal damage on histopathology.
- Neonatal DWI may overestimate the extent of eventual cystic lesions in surviving neonates.