Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rhabdomyolysis: a review.

Jason D Warren1, Peter C Blumbergs, Philip D Thompson

  • 1Department of Neurology, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Muscle & Nerve
|March 1, 2002
PubMed
Summary

Rhabdomyolysis, a skeletal muscle breakdown syndrome, can lead to acute kidney injury. Advances in genetics and histochemistry aid in diagnosing recurrent rhabdomyolysis causes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.

European journal of neurology·2026
Same author

Music processing in behavioural variant frontotemporal dementia and Alzheimer's disease: a functional MRI study.

Brain communications·2026
Same author

Non-verbal dichotic listening: A new cognitive hearing test for dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia.

Brain communications·2026
Same author

Barriers and Facilitators to Implementing Synchronous Telehealth Interventions for People With Dementia - A Systematic Review.

Dementia (London, England)·2026
Same author

Subjective time perception in dementia: a behavioural and neuroanatomical analysis.

Brain communications·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • Rhabdomyolysis involves skeletal muscle breakdown, releasing myoglobin and potentially causing acute kidney injury.
  • Causes are diverse, including inherited/acquired disorders affecting muscle membranes, ion channels, and energy metabolism.
  • Pathophysiology often involves elevated intracellular calcium and protease activation, leading to muscle fiber destruction.

Purpose of the Study:

  • To elucidate the pathophysiology of rhabdomyolysis.
  • To highlight the role of intracellular calcium and proteases.
  • To explore the diagnostic potential of molecular genetics and histochemistry for idiopathic recurrent rhabdomyolysis.

Main Methods:

  • Review of existing literature on rhabdomyolysis.
  • Analysis of pathophysiological mechanisms.
  • Discussion of diagnostic advancements.

Main Results:

  • Identified common pathways in rhabdomyolysis, including calcium dysregulation and protease activation.
  • Highlighted the link between muscle breakdown and renal complications.
  • Emphasized the growing role of genetic and histochemical analyses.

Conclusions:

  • Understanding the molecular basis of rhabdomyolysis is crucial for managing associated renal failure.
  • Specific metabolic diagnoses are increasingly feasible for idiopathic recurrent rhabdomyolysis.
  • Further research into muscle energy pathways and ion channel function is warranted.

Related Experiment Videos