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Immunotherapy of sepsis
1Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Centre, University of Amsterdam, Netherlands. T.vanderPoll@amc.uva.nl
The Lancet. Infectious Diseases
|March 2, 2002
Summary
Sepsis, a severe infection response, has high mortality. This review examines immunomodulatory strategies, focusing on those clinically evaluated to improve patient outcomes.
Area of Science:
- * Critical care medicine and immunology.
- * Host-pathogen interactions and inflammatory diseases.
Background:
- * Sepsis is a life-threatening systemic host response to infection with high mortality rates (30-40%).
- * It involves complex inflammatory pathways, including cytokine networks and coagulation.
- * Sepsis can lead to immune suppression, increasing susceptibility to secondary infections.
Purpose of the Study:
- * To review immunomodulatory strategies for sepsis treatment.
- * To focus on therapies that have advanced to clinical evaluation.
Main Methods:
- * Literature review of preclinical and clinical studies on immunomodulation in sepsis.
- * Analysis of studies investigating host response modulation as adjunctive therapy.
Main Results:
- * Significant advancements in understanding sepsis pathogenesis over the past 20 years.
- * Identification of various immunomodulatory approaches tested in clinical settings.
Conclusions:
- * Immunomodulatory strategies represent a key area of research for improving sepsis outcomes.
- * Clinical evaluation of these strategies is crucial for translating preclinical findings into effective treatments.