Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malaria, quinine and red cell lysis.

H Laser, P Kemp, N Miller

    Parasitology
    |October 1, 1975
    PubMed
    Summary

    This study explains red blood cell lysis in malaria and how quinoline and acridine drugs work. These antimalarial drugs promote parasite-infected red blood cell lysis, aiding treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Revision endoscopic sinus surgery is rarely needed in dupilumab-treated chronic rhinosinusitis with nasal polyps.

    Rhinology·2026
    Same author

    The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

    Tribology letters·2025
    Same author

    Eosinophilic complications during dupilumab therapy for type 2 diseases: a systematic review.

    Rhinology·2025
    Same author

    Hypereosinophilia during dupilumab treatment in patients with chronic rhinosinusitis with nasal polyps.

    Rhinology·2023
    Same author

    Evaluation of droplet-vitrification, vacuum infiltration vitrification and encapsulation-dehydration for cryopreservation of Syzygium maire zygotic embryos.

    Cryo letters·2022
    Same author

    An app with brief behavioural support to promote physical activity after a cancer diagnosis (APPROACH): study protocol for a pilot randomised controlled trial.

    Pilot and feasibility studies·2022

    Area of Science:

    • Malariology
    • Pharmacology
    • Cell Biology

    Background:

    • Acute malaria infections cause red blood cell lysis.
    • The mechanism of action for quinoline and acridine antimalarial drugs requires further elucidation.
    • Protein inhibition of fatty acid-induced red blood cell lysis is a known phenomenon.

    Purpose of the Study:

    • To propose a hypothesis explaining red blood cell lysis during acute malaria.
    • To elucidate the mode of action of quinoline and acridine antimalarial drugs.
    • To investigate the interaction between protein, fatty acids, and red blood cell lysis in the context of antimalarial drug activity.

    Main Methods:

    • An in vitro system was utilized to test the effects of antimalarial drugs.
    • The study focused on fatty acid-induced red blood cell lysis.
    • Experiments assessed the ability of drugs to counteract protein-mediated inhibition of lysis.

    Main Results:

    • Quinine and other antimalarial drugs were found to counteract protein inhibition of fatty acid-induced lysis.
    • This counteraction suggests a novel mechanism for antimalarial drug efficacy.
    • The findings provide a potential explanation for red cell lysis observed in malarial infections.

    Conclusions:

    • Antimalarial drugs, specifically those in the quinoline and acridine series, may exert their chemotherapeutic effect by inducing premature lysis of parasitized red blood cells.
    • This premature lysis is proposed to occur through the relief of protein-mediated inhibition of hemolysis.
    • The hypothesis offers a unified explanation for both red cell destruction in malaria and the action of key antimalarial drugs.

    Related Experiment Videos