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Updated: Aug 17, 2026

Automated Measurement of Microcirculatory Blood Flow Velocity in Pulmonary Metastases of Rats
Published on: November 30, 2014
Alteration of metastases distribution by vaso-dilating drugs
Abstract:
The effects of the two vasodilating substances, dihydralazine and the adrenergic alpha-receptor blocker phenoxybenzamine, were studied on the distribution and growth of MCG-L-SS metastases from intravenously injected tumour cells. Dihydralazine increased the total number of metastases in the body and both drugs increased the number in the lungs and the liver. Both drugs also increased the total metastasis volume in the liver. The effects might be secondary to the haemodynamic effects of the drugs, e.g. a changed distribution of the blood flow, more open capillaries and/or a changed hydrostatic capillary pressure.
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