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The release of gentamycin into the wound secretions from polymethylmethacrylate beads. A study with reference to the
Abstract:
Following implantation of Gentamycin PMMA beads, the concentration of antibiotics in the wound secretion was investigated in an animal experiment which corresponded to the clinically applied procedure. The measured concentrations of active substance over a period of 6 days were on an average 8 times higher than the maximum serum titers obtainable with systemic application of antibiotics, and consequently they exceeded by several dilution stages the minimum bactericidal concentrations of most of those bacteria which are responsible for infections of wounds and bones. The kinetics of release of Gentamycin out of the PMMA beads are presented, and compared with that of bone cement which contains antibiotics and which is used in endoprostheses. From the results, conclusions about the intraoperative techniques which should be realised have been drawn, conditions which are of decisive importance for the success of this new treatment for infections of the bone and soft tissue.
Insights
Gentamycin PMMA beads deliver high antibiotic concentrations in wound secretions, exceeding systemic levels and minimum bactericidal concentrations for bone and soft tissue infections. This study details release kinetics and guides optimal intraoperative techniques for effective treatment.
Area of Science:
- Orthopedics
- Infectious Diseases
- Biomaterials
Background:
- Bone and soft tissue infections pose significant treatment challenges.
- Systemic antibiotic delivery often fails to achieve therapeutic concentrations at the infection site.
- Polymethyl methacrylate (PMMA) beads offer a localized drug delivery approach.
Purpose of the Study:
- To investigate the antibiotic concentration and release kinetics of Gentamycin PMMA beads in wound secretions.
- To compare Gentamycin release from PMMA beads with antibiotic-loaded bone cement.
- To determine optimal intraoperative techniques for treating bone and soft tissue infections using Gentamycin PMMA beads.
Main Methods:
- An animal experimental model was used, mimicking clinical implantation of Gentamycin PMMA beads.
- Antibiotic concentrations in wound secretions were measured over a 6-day period.
- Gentamycin release kinetics from PMMA beads were analyzed and compared to antibiotic-loaded bone cement.
Main Results:
- Concentrations of Gentamycin in wound secretions averaged 8 times higher than maximum achievable serum titers via systemic application.
- Measured concentrations significantly exceeded minimum bactericidal concentrations for common bone and wound pathogens.
- Kinetics of Gentamycin release from PMMA beads were characterized.
Conclusions:
- Gentamycin PMMA beads provide superior local antibiotic concentrations compared to systemic administration.
- The study provides crucial data for optimizing intraoperative techniques for effective infection treatment.
- This localized delivery method shows promise for managing bone and soft tissue infections.