Related Experiment Videos
Factors associated with the reduction of bone density in patients with gonadal dysgenesis
Cristina L Benetti-Pinto1, Aloisio Bedone, Luís A Magna
1Gynecological Endocrinology Clinic, Department of Obstetrics and Gynecology, School of Medicine, Universida de Estadual de Campinas, Campinas, Brazil. crislag@sigmanet.com.br
Objective:
To correlate bone mineral density (BMD) in women with primary hypoestrogenism caused by 46,XX pure gonadal dysgenesis or Turner's syndrome with age, age at estrogen therapy initiation, length of estrogen use, and body mass index (BMI).
Design:
Cross-sectional study.
Setting:
Academic tertiary-care hospital.
Patient(S):
Thirty-eight women, aged 16 to 35 years (mean, 24.6 years), affected by these genetic disorders.
Intervention(S):
Measurement of lumbar spine and femoral neck BMD using double x-ray absorptiometry. The results were correlated with the control variables by using Pearson's coefficient of correlation. Variables associated with BMD were evaluated by multiple linear regression analysis.
Main Outcome Measure(S):
Bone mineral density.
Result(S):
Bone mineral density of the lumbar spine showed that 90% of the women presented osteopenia or osteoporosis. The femoral neck was affected in 55% of these women. The length of estrogen therapy and the BMI showed a positive association with BMD at the lumbar spine and femoral neck, respectively.
Conclusion(S):
Women affected by pure gonadal dysgenesis or Turner's syndrome presented a marked decrease in BMD of the lumbar spine and femoral neck. Medical attention for their diagnosis and early hormone replacement therapy are advised.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:28Menopause
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:24Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
01:40Bone Remodeling
02:07Oogenesis