Related Experiment Video

Updated: Oct 2, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects

Peter M Emmer1, Eric A P Steegers, Marié Jose van Lierop

  • 1Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, Geert Grooteplein 10, PO Box 9101, 6500 HB, huispost 603/ABTI, Nijmegen, The Netherlands.

Early Human Development
|March 2, 2002
PubMed

Pregnancies affected by a neural tube defect show changes in thymus morphology, neonatal and maternal T-cell repertoire. Amniotic fluid levels of soluble human leukocyte antigen G (HLA-G) (an immuno-modulatory protein) were found to be significantly lower as compared to controls. This may reflect a diminished cell-mediated immunity in neural tube defects.

More Related Videos

Isolation of Leukocytes from the Human Maternal-fetal Interface08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...