Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin resistance and vascular function.

Alain D Baron1

  • 1Indiana University School of Medicine, Indianapolis, IN, USA. abaron@amylin.com

Journal of Diabetes and Its Complications
|March 2, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insulin resistance in the vasculature.

The Journal of clinical investigation·2013
Same author

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats.

Cardiovascular diabetology·2010
Same author

The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men.

The journal of sexual medicine·2008
Same author

Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans.

American journal of physiology. Endocrinology and metabolism·2008
Same author

Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms.

Endocrinology·2008
Same author

Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same journal

Diabetes and the risk of entrapment neuropathies of the upper and lower extremity - A propensity score-matched cohort study.

Journal of diabetes and its complications·2026
Same journal

Evaluation of the protective effects of liraglutide, dapagliflozin and their combination in rat kidneys of streptozotocin induced diabetes.

Journal of diabetes and its complications·2026
Same journal

From obesity guideline to diabetes practice: WHO GLP-1 recommendations between promise, uncertainty and global inequity.

Journal of diabetes and its complications·2026
Same journal

Impact of the AWGS2025 criteria on sarcopenia prevalence and microvascular complications in individuals with type 2 diabetes in Japan: a cross-sectional study.

Journal of diabetes and its complications·2026
Same journal

Clinical inertia in patients with type 2 diabetes: A retrospective cohort study using an electronic healthcare database in Japan.

Journal of diabetes and its complications·2026
Same journal

From static lipids to dynamic risk: The role of atherogenic index of plasma in prediabetes.

Journal of diabetes and its complications·2026
See all related articles

Insulin acts as a vasoactive hormone, promoting vasodilation. Insulin resistance impairs this function and increases cardiovascular disease risk due to linked signaling defects.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Insulin is recognized as a vasoactive hormone, mediating endothelial-nitric oxide-dependent vasodilation.
  • Insulin resistance is characterized by diminished insulin-mediated glucose uptake and impaired vasodilation.
  • Elevated free fatty acids in insulin resistance contribute to endothelial dysfunction.

Purpose of the Study:

  • To explore the link between insulin's metabolic and vascular actions.
  • To investigate shared insulin signaling mechanisms in peripheral tissues and endothelium.
  • To elucidate the role of endothelial dysfunction in insulin resistance-associated cardiovascular disease risk.

Main Methods:

  • Review of recent data on insulin signaling and vascular function.

Related Experiment Videos

  • Analysis of the impact of insulin resistance and free fatty acids on endothelial function.
  • Examination of shared signaling pathways in metabolic and vascular tissues.

    • Main Results:

    • Insulin resistance is associated with impaired insulin-mediated vasodilation.
    • Shared defects in insulin signaling may underlie both metabolic and vascular dysfunction.
    • Endothelial dysfunction in insulin resistance is linked to common signaling defects.

    Conclusions:

    • Insulin's metabolic and vascular actions are closely interconnected.
    • Common defects in insulin signaling present a unified mechanism for insulin resistance and endothelial dysfunction.
    • This provides a parsimonious explanation for the increased cardiovascular disease risk in insulin resistance.