Related Experiment Videos
Primary cutaneous plasmacytoma on chronic lymphoedema
Monica Corazza1, Annarita Lombardi, Renata Strumia
1Department of Medicina Clinica e Sperimentale-Sezione Dermatologia, Università degli Studi di Ferrara, Via Savonarola 9, 44100 Ferrara, Italy. czm@unife.it
European Journal of Dermatology : EJD
|March 2, 2002
Summary
A rare case of cutaneous plasmacytoma, a plasma cell tumor on the skin, was diagnosed in an elderly man with chronic leg swelling. Treatment with melphalan and prednisone was successful, with no disease recurrence observed over two years.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Cutaneous plasmacytoma is a rare plasma cell neoplasm primarily affecting the skin.
- Chronic lymphedema is a condition characterized by persistent swelling, often in the limbs.
- The association between chronic lymphedema and cutaneous plasmacytoma is infrequently reported.
Observation:
- A 77-year-old male patient presented with multiple cutaneous lesions.
- The patient had a history of chronic lymphedema affecting his lower limbs.
- Histopathology and immunohistochemical staining confirmed the diagnosis of cutaneous plasmacytoma.
Findings:
- Staging investigations ruled out any extracutaneous involvement, indicating localized disease.
- The patient received treatment with a combination of melphalan and prednisone.
- The cutaneous lesions showed a complete response to the chemotherapy regimen.
Implications:
- This case highlights the importance of considering cutaneous plasmacytoma in patients with chronic lymphedema.
- Successful treatment with melphalan and prednisone suggests this regimen is effective for localized cutaneous plasmacytoma.
- Long-term follow-up confirmed the absence of disease progression, supporting the efficacy of the chosen treatment strategy.