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Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted
N Nighoghossian1, M Hermier, P Adeleine
1Cerebrovascular Disease Center, and CREATIS UMR CNRS 5515, Lyon, France. norbert.nighoghossian@chu-lyon.fr
Stroke
|March 2, 2002
Summary
Microbleeds (MBs) detected by T2*-weighted MRI may increase the risk of cerebral bleeding (CB) after ischemic stroke. Patients with MBs showed a higher incidence of CB, indicating associated vascular vulnerability.
Area of Science:
- Neurology
- Radiology
- Cardiovascular Research
Background:
- Microbleeds (MBs) on T2*-weighted MRI indicate microangiopathy and may be a risk factor for cerebral bleeding (CB) post-ischemic stroke.
- Understanding the link between MBs and CB is crucial for predicting stroke outcomes.
Purpose of the Study:
- To assess the impact of MBs on the occurrence of CB after cerebral infarction.
- To identify predictors of CB in patients with ischemic stroke.
Main Methods:
- Prospective study of 100 ischemic stroke patients within 24 hours of symptom onset.
- Utilized T2*-weighted gradient-echo MRI for MB detection and CT scans for CB verification.
- Assessed MBs as signal loss areas on T2*-weighted images and CB using MRI and CT.
Main Results:
- Microbleeds (MBs) were present in 20% of patients.
- Significant predictors of MBs included age, diabetes, antithrombotic drug use, atherothrombotic stroke source, and lacunar infarct.
- Cerebral bleeding (CB) occurred in 26% of patients; baseline NIH Stroke Scale score, diabetes, and MBs were independent predictors of CB.
Conclusions:
- The presence of MBs is associated with an increased risk of cerebral bleeding (CB) after ischemic stroke.
- Vascular vulnerability linked to MBs likely contributes to the development of CB.
- MBs serve as a significant predictor of CB in ischemic stroke patients.