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Related Experiment Videos

Is isoflurane-induced preconditioning dose related?

Franz Kehl1, John G Krolikowski, Boris Mraovic

  • 1Department of Anesthesiology, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA.

Anesthesiology
|March 2, 2002
PubMed
Summary

Isoflurane, a volatile anesthetic, protects the heart against infarction in a dose-dependent manner. Even low concentrations (0.25 minimum alveolar concentration) offer significant cardioprotection, with higher doses providing enhanced benefits.

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Area of Science:

  • Cardiology
  • Anesthesiology
  • Cardiovascular Research

Background:

  • Volatile anesthetics are known to precondition the myocardium, offering protection against myocardial infarction.
  • The dose-dependency of this cardioprotective effect remains incompletely understood.

Purpose of the Study:

  • To investigate whether isoflurane confers myocardial protection against infarction in a dose-dependent manner in vivo.
  • To determine the minimum effective concentration of isoflurane for cardioprotection.

Main Methods:

  • Forty anesthetized dogs underwent 60-minute coronary artery occlusion followed by 3-hour reperfusion.
  • Dogs were randomly assigned to receive varying concentrations of isoflurane (0.0 to 1.25 minimum alveolar concentration [MAC]) administered prior to occlusion.

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  • Systemic hemodynamics and infarct size were measured.

    • Main Results:

    • Isoflurane significantly reduced infarct size compared to controls (29% vs. 11-17% of area at risk).
    • Cardioprotection was observed at concentrations as low as 0.25 MAC.
    • Higher isoflurane concentrations demonstrated a dose-dependent enhancement of cardioprotection, particularly under conditions of low collateral blood flow.

    Conclusions:

    • Isoflurane effectively preconditions the myocardium against infarction, with effects observed at low concentrations (0.25 MAC).
    • Higher concentrations of isoflurane may offer superior myocardial protection, especially when coronary collateral blood flow is compromised.