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Related Experiment Videos

Constrictive pericarditis in chronic ulcerative colitis.

Amy S Oxentenko1, Edward V Loftus, Jae K Oh

  • 1Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

Journal of Clinical Gastroenterology
|March 2, 2002
PubMed
Summary
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This study reports the first case of constrictive pericarditis linked to inflammatory bowel disease (IBD) or its treatment. The patient, with chronic ulcerative colitis, developed constrictive pericarditis after starting mesalamine.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Internal Medicine

Background:

  • Acute pericarditis is an established extraintestinal manifestation of inflammatory bowel disease (IBD).
  • IBD treatments like sulfasalazine and mesalamine have been linked to acute pericarditis.
  • No prior cases of constrictive pericarditis associated with IBD or its treatments were documented.

Observation:

  • A 37-year-old woman with a 24-year history of chronic ulcerative colitis (CUC) presented with symptoms of constrictive pericarditis.
  • Her symptoms began after initiating oral mesalamine for a CUC flare.
  • Physical examination and echocardiography confirmed constrictive pericarditis with diastolic compromise.

Findings:

  • The patient underwent a radical pericardectomy for hemorrhagic acute and chronic pericarditis.

Related Experiment Videos

  • Pathological examination revealed no infectious causes.
  • This is the first reported case of constrictive pericarditis associated with IBD or its treatment.

    • Implications:

    • This case highlights a potential serious cardiac complication of IBD and its therapies.
    • It suggests that mesalamine may induce constrictive pericarditis, in addition to acute pericarditis.
    • Further investigation is warranted to elucidate the mechanisms and incidence of drug-induced constrictive pericarditis in IBD patients.