Toxicological evaluation of a new benzonaphtyridone derivative (IF C-45)

DL50 for 10-gamma-dimethylaminopropyl-7-chlorobenzo(b)-(1-8)-naphtyridone-5 hydrochloride (IF C-45) determined on several species of animals at different ways of administration, had values similar to those of imipramine and amitryptyline. IF C-45 a-cumulates in 34-4% of A-DL50. The evaluation of chronic toxicity was performed on rats, giving IF C-45 daily for 3 months the doses of 30, 25 and 12-5 mg/kg. The results of hematological, biochemical and histological estimations did not show in these animals any marked toxic effects.