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Sodium-coupled bicarbonate transporters.

W F Boron¹

¹Department of Cell and Molecular Physiology, Yale University School of Medicine. New Haven, CT 06520-8026, USA. walter.boron@yale.edu

JOP : Journal of the Pancreas

|March 5, 2002

Summary

The bicarbonate transporter (BT) superfamily, including Na(+)-coupled HCO(3)(-) transporters and anion exchangers, regulates intracellular pH (pH(i)) and cell volume. Most BTs are inhibited by 4,4'-diisothiocyanostilbene-4,4'-disulfonate (DIDS).

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Area of Science:

Physiology
Molecular Biology
Biochemistry

Background:

The bicarbonate transporter (BT) superfamily includes Na(+)-coupled HCO(3)(-) transporters and anion exchangers (AEs).
BTs are crucial for regulating intracellular pH (pH(i)) and cell volume across various cell types.
Specific BTs facilitate salt and acid-base transport in epithelia.

Purpose of the Study:

To elucidate the diverse roles of bicarbonate transporters in physiological processes.
To highlight the functions of specific BT families, including NBCe, NBCn, and NDCBE.
To identify common inhibitory characteristics of BTs.

Main Methods:

The study synthesizes existing knowledge on bicarbonate transporter families.
It reviews the physiological roles and locations of various BTs.
It discusses the inhibitory effects of 4,4 -diisothiocyanostilbene-4,4 -disulfonate (DIDS) on BTs.

Main Results:

Electrogenic Na/HCO3 cotransporters (NBCe) are vital for renal and pancreatic transport.
Electroneutral NBCs (NBCn) regulate pH(i) in vascular smooth muscle and the brain.
Na(+)-driven Cl-HCO3 exchangers (NDCBE) are key pH(i) regulators in CNS neurons.

Conclusions:

Bicarbonate transporters are essential for maintaining cellular homeostasis and physiological functions.
Distinct BT families have specialized roles in different tissues and organs.
The majority of BTs share sensitivity to the inhibitor DIDS.

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