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Updated: Aug 10, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
[Etiology of non-melanoma skin cancer]
1Det medisinske fakultet Universitetet i Oslo, Hudavdelingen Rikshospitalet, Oslo. petter.gjersvik@rikshospitalet.no
Background:
Most countries are experiencing an increased incidence of non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma).
Material And Methods:
Based on relevant literature found by search in the PubMed database, an overview of the present knowledge of the etiology and pathogenesis of non-melanoma skin cancer is given.
Results:
DNA damage caused by ultraviolet (UV) radiation from the sun is the main cause of non-melanoma skin cancer. Failure to repair these genetic alterations leads to unrestrained growth and ultimately tumour formation. In addition, ultraviolet radiation induces a relative immunosuppression in the skin that prevents cutaneous tumour rejection. UV-specific mutations in the p53 tumour suppressor gene probably play an important role through both tumour initiation and cell selection.
Interpretation:
Physicians should advise their patients to avoid unnecessary sun exposure and to use sun protection, including sun screen creams.
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