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[Pharmacomodulation of hypersensitivity rhinitis]
D Ursulović1, L Janosević, S Janosević
1Institut za medicinu rada, Klinicki centar Srbije, 11000 Beograd, Deligradska 29. 08otits@infosky.net
Medicinski Pregled
|March 6, 2002
Summary
Local corticosteroid treatment significantly reduced eosinophils in patients with hypersensitive rhinitis. This study highlights beclomethasone
Area of Science:
- Allergy and Immunology
- Otorhinolaryngology
- Pharmacology
Background:
- Hypersensitive rhinitis involves nasal mast cell and eosinophil accumulation.
- Treatments aim to reduce cell accumulation or mediator effects.
- Eosinophils are key effector cells in nasal inflammation.
Purpose of the Study:
- To investigate local corticosteroid effects on nasal eosinophils in hypersensitive rhinitis.
- To assess beclomethasone dipropionate's impact on eosinophil counts.
- To understand corticosteroid therapy's role in rhinitis pathogenesis.
Main Methods:
- Prospective controlled trial with 55 hypersensitive rhinitis patients.
- Experimental group received beclomethasone dipropionate nasal spray (400 mcg/day) for 6 weeks.
- Control group received no active treatment; both groups underwent regular ENT and cytological examination.
Main Results:
- Significant reduction in nasal eosinophils in the beclomethasone group.
- Insignificant changes in eosinophil counts in the control group.
- Beclomethasone demonstrated a strong antieosinophilic effect.
Conclusions:
- Local corticosteroid therapy effectively reduces eosinophils in hypersensitive rhinitis.
- This reduction likely modulates the inflammatory process.
- Potential delays in eosinophil apoptosis may involve interleukin-5 signaling.