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Quantification of coronary risk score
Tejinder Singh1, Shubhro Sumit Mullick, Rajneesh Calton
1Department of Pediatrics, Christian Medical College & Hospital, Ludhiana. drtejinder@pediatrician.com
Insights
Children with a family history of coronary artery disease (CAD) have higher future cardiovascular risk. This increased risk is primarily linked to biochemical factors like high triglycerides.
Area of Science:
- Cardiovascular Medicine
- Pediatric Cardiology
- Preventive Cardiology
Background:
- Coronary artery disease (CAD) has a significant familial component.
- Early identification of cardiovascular risk in pediatric populations with a family history of CAD is crucial for preventive strategies.
Purpose of the Study:
- To quantify the coronary risk score in children and grandchildren of patients diagnosed with coronary artery disease (CAD).
- To investigate the association between a positive family history of CAD and elevated cardiovascular risk scores in offspring.
Main Methods:
- A case-control study involving 150 children with a positive family history of CAD (cases) and 150 age/sex-matched controls.
- Biochemical assessments included fasting blood sugar, serum cholesterol, and triglycerides.
- Coronary risk scores were calculated using Nora's risk assessment scheme.
Main Results:
- Children with a family history of CAD exhibited significantly higher triglyceride levels (p < 0.005) and a threefold increased prevalence of hypertriglyceridemia (p < 0.001).
- Cases demonstrated substantially higher overall risk scores (p < 0.00001) compared to controls.
- The elevated risk scores in cases were predominantly attributed to biochemical risk factors (p < 0.0006).
Conclusions:
- A positive family history of CAD in children and grandchildren is associated with significantly elevated future CAD risk scores.
- Biochemical derangements, particularly hypertriglyceridemia, are the primary drivers of increased cardiovascular risk in this pediatric cohort.
Objective:
To quantify the coronary risk score in children and/or grandchildren of patients with coronary artery disease (CAD).
Methods:
One hundred and fifty children with positive family history of CAD (cases) and age and sex matched children with no such history (controls) were enrolled in the study. Fasting blood sugar, serum cholesterol and triglycerides were estimated on all children and a risk score was calculated using Nora's scheme.
Result:
The cases and controls were similar with respect to mean age, six distribution, mean weight and mean height. None of the child was hypertensive. Mean serum levels of triglycerides were 164.7 m/dl and 105.7 mg% respectively in cases and controls (p < 0.005). Prevalence of hypertriglyceridemia was three times more in cases (p < 0.001). Cases had a significantly higher risk scores (p < 0.00001) and this was mainly attributable to higher biochemical risk (P < 0.0006).
Conclusion:
Children and grand children with a positive family history of CAD had significantly higher risk scores for future CAD. The increased risk was mainly due to biochemical derangements.