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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

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Related Experiment Video

Updated: Jun 27, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

Antipyretics in children.

Jagdish Chandra1, Shishir Kumar Bhatnagar

  • 1Department of Pediatrics, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi, India. bshishir@rediffmail.com

Indian Journal of Pediatrics
|March 6, 2002
PubMed
Summary
This summary is machine-generated.

Fever in children can cause serious complications. Combining physical therapy with paracetamol is the safest and most effective method for reducing fever in pediatric patients.

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Last Updated: Jun 27, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography
06:29

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Published on: November 29, 2017

Area of Science:

  • Pediatrics
  • Physiology
  • Pharmacology

Background:

  • Fever is a common symptom in children, often indicating an underlying illness.
  • Fever can lead to adverse effects such as febrile seizures, dehydration, and increased respiratory effort.
  • The hypothalamus regulates body temperature, and fever results from prostaglandin-induced resetting.

Purpose of the Study:

  • To review the harmful effects of fever in pediatric patients.
  • To explore various methods of fever management in children.
  • To determine the most effective and safest approach to reducing fever in pediatric age groups.

Main Methods:

  • Literature review of fever's pathophysiology and treatment options.
  • Analysis of pharmacological antipyretic mechanisms.
  • Evaluation of physical therapy interventions for fever reduction.

Main Results:

  • Fever can cause significant physiological stress in children, particularly those with compromised circulation.
  • Pharmacological agents like paracetamol, nimesulide, and ibuprofen reduce fever by inhibiting prostaglandin synthesis.
  • Paracetamol is identified as the safest antipyretic drug available.

Conclusions:

  • A combination of physical therapy, such as tepid sponging, and paracetamol administration is recommended.
  • This combined approach offers a safe and cost-effective strategy for managing fever in children.
  • Effective fever control is crucial for preventing complications in the pediatric population.