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Updated: Oct 2, 2026
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
[An experimental study of antibiotic -- induced endotoxin release in Pseudomonas aeruginosa bacteremia inburned rats]
1Intitute of Burn Research, Union Hospital, Fuijian Medical University, Fuzhou, 350001, China.
Objective:
To assess the intensity of endotoxin release in Pseudomonas aeruginosa challenged burned rats after the administration of various antibiotics.
Methods:
Rats were inflicted with 30% TBSA burn, and they were challenged with Pseudomonas aeruginosa (PA103). After the administration of different beta lactam antibiotics, serum endotoxin level and blood bacterial count were determined.
Results:
All the antibiotics used were effective in eradicating the bacteria with concomitant release of endotoxin in varying amounts. It was found that Imipenem released the least amount of endotoxin, followed in order by Cefoperazone, Ceftazidime, and Cefotxime.
Conclusions:
Different antibiotics possessed varying capacity of inducing endotoxin release from PA, and the amount released did not bear any relation with the bactericidal capability of the antibiotics.
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