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Published on: February 18, 2015
[A study of cytokines in pathogenesis of thyroid-related immune orbitopathy]
1Department of Ophthalmology, Second Hospital of Tianjin Medical University, Tianjin 300211.
Objective:
To explore the pathogenesis of thyroid-related immune orbitopathy (TRIO).
Methods:
Human orbital fibroblasts were cultured in vitro and immunohistochemical techniques were used to study cytokines that induce effect on HLA-II antigen expression of orbital fibroblasts.
Results:
It is shown that interferon-gamma (IFN-gamma), interleukin-1 (IL-1) and tumor necrosis factor (TNF) could induce the expression of orbital fibroblast HLA-II antigens. The induced effect of IFN-gamma is of good linear correlations with time and concentration.
Conclusion:
HLA-II antigen expression can be induced by IFN-gamma, IL-1 and TNF. In the course of immune reaction and pathogenesis of TRIO, cytokines play important roles.
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