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Nutritional outcome and growth of children after intestinal transplantation

Kishore Iyer1, Simon Horslen, Angie Iverson

  • 1Section of Transplantation, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.

Journal of Pediatric Surgery
|March 6, 2002
PubMed

Insights

Pediatric intestinal transplantation enables full enteral nutrition. However, children experience significant growth inhibition during transplantation and lack catch-up growth post-procedure.

Area of Science:

  • Pediatric Surgery
  • Transplantation Medicine
  • Pediatric Gastroenterology

Background:

  • Intestinal transplantation is a complex procedure for children with intestinal failure.
  • Nutritional status and growth are critical outcomes following pediatric transplantation.
  • Long-term graft function and patient survival are key considerations.

Purpose of the Study:

  • To evaluate the nutritional outcomes in children post-intestinal transplantation.
  • To assess linear growth patterns in pediatric recipients after successful intestinal transplantation.

Main Methods:

  • Retrospective case-record review of pediatric patients undergoing intestinal transplantation.
  • Inclusion criteria: graft survival of at least 1 year.
  • Data collection from outpatient charts and computerized databases.

Main Results:

  • 47 intestinal transplants were performed in 46 children (isolated small bowel or combined liver-small bowel).
  • Survivors with functioning grafts achieved full enteral nutrition.
  • Significant pre-transplant growth inhibition was observed, with no catch-up growth post-transplant.

Conclusions:

  • Successful intestinal transplantation facilitates the establishment of full enteral feeding.
  • Severe linear growth inhibition at the time of transplantation is a significant concern.
  • Post-transplant growth velocity is maintained but does not show catch-up growth.
Abstract

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