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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

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Published on: January 27, 2023

Infants with single ventricle: a population-based epidemiological study.

Eileen K Steinberger¹, Charlotte Ferencz, Christopher A Loffredo

¹Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

|March 6, 2002

Summary

Paternal alcohol and smoking are linked to single ventricle heart defects in infants. These environmental factors may play a role in the development of this rare congenital condition.

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Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

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Published on: June 9, 2023

Area of Science:

Pediatric Cardiology
Congenital Heart Defects
Epidemiology

Background:

Single ventricle is a rare congenital cardiac defect.
It often occurs within complex cardiovascular abnormalities.
Epidemiologic associations are not well understood.

Purpose of the Study:

To investigate epidemiologic associations of single ventricle.
To evaluate infant, family, and parental exposure factors.
To analyze associations based on cardio-visceral situs.

Main Methods:

Population-based case-control study using Baltimore-Washington Infant Study (BWIS) data (1981-89).
Evaluated 55 infants with single ventricle against 3,572 controls.
Used odds ratios and 95% confidence intervals to measure associations.

Main Results:

Paternal alcohol consumption (OR=2.0) and smoking (OR=2.4) associated with all single ventricle cases.
Associations were stronger in infants with abnormal situs.
Maternal abortion history (OR=3.2) and paternal marijuana use (OR=2.2) also showed associations.

Conclusions:

Paternal smoking and alcohol consumption identified as potential risk factors.
Highlights the need to consider environmental factors in single ventricle pathogenesis.
Further research is warranted.