Search research articles

Search research articles

Related Experiment Videos

[Septic shock and selenium administration].

X Forceville¹, P Aouizerate, M Guizard

¹Centre Hospitalier de Meaux, 6-8 rue Saint-Fiacre, BP 218, 77104 Meaux, France.

|March 7, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Acquired acral melanocytic lesions in children and adolescents].

Annales de dermatologie et de venereologie·2020

Same author

Role of both actin-myosin cross bridges and NO-cGMP pathway modulators in the contraction and relaxation of human placental stem villi.

Placenta·2013

Same author

Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2009

Same author

[Performances of an automated dispensing system combined with a computerized prescription order entry].

Annales pharmaceutiques francaises·2009

Same author

[Management of heparin-induced thrombocytopenia].

Therapie·2003

Same author

[Development of surgical antibioprophylaxis kits: evaluation of the impact on prescribing habits].

Therapie·2002

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Selenium, an essential trace element, is crucial for enzyme activity and reactive oxygen species detoxification. In septic shock patients, selenium levels decrease, and supplementation shows promise, though further research is needed for optimal dosing.

Area of Science:

Biochemistry
Trace Element Metabolism
Enzymology

Context:

Selenium is an essential trace element vital for antioxidant enzyme function, including glutathione peroxidases and thioredoxin reductase.
In septic shock, excessive reactive oxygen species contribute to tissue damage, while plasma selenium levels significantly decrease.
The role of selenium in mitigating oxidative stress and its impact on inflammatory pathways in sepsis is an area of active investigation.

Purpose:

To review the role of selenium in the context of sepsis and septic shock.
To examine the evidence for selenium supplementation in managing severe infections and associated oxidative stress.
To provide recommendations for selenium administration in critically ill patients based on current literature.

Summary:

Related Experiment Videos

Selenium, as selenocysteine, is integral to antioxidant enzymes that detoxify reactive oxygen species (ROS).
Septic shock patients exhibit early and marked plasma selenium depletion, potentially due to redistribution for metabolic needs.
While preliminary studies suggest selenium treatment may be beneficial in severe sepsis, robust clinical data is lacking, necessitating cautious dosing within physiological limits.

Impact:

Understanding selenium's role in sepsis can inform therapeutic strategies to combat oxidative stress and improve patient outcomes.
Further well-designed clinical trials are required to establish optimal selenium dosage and efficacy in septic patients.
This review highlights the potential of selenium as an adjunctive therapy in critical care settings, emphasizing the need for evidence-based guidelines.