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[Primary neoplasm of unknown origin].

P Ferreira1, R Lebre, A Rodrigues

  • 1Serviço de Medicina III, Hospitais da Universidade de Coimbra, Coimbra.

Acta Medica Portuguesa
|March 7, 2002
PubMed
Summary

Cancer of unknown primary site (CUP) affects 2.5% of patients, with adenocarcinoma being the most common type. Prognosis remains poor due to aggressive disease and limited effective therapies.

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Area of Science:

  • Oncology
  • Internal Medicine

Context:

  • Cancer of unknown primary site (CUP) represents a significant clinical challenge.
  • Analysis of patient data from the University Hospital of Coimbra between 1992 and 1998.

Purpose:

  • To analyze the prevalence, characteristics, and outcomes of cancer of unknown primary site.
  • To evaluate the diagnostic skill and prognostic factors in CUP cases.

Summary:

  • The study identified 26 patients with CUP, representing 2.5% of malignant neoplasias.
  • The median age was 64 years, with a male-to-female ratio of 4.2:1.
  • Well-differentiated adenocarcinoma was the most frequent histological type (46.1%).
  • The three-year global survival rate was critically low at 3.9%.

Impact:

  • The prevalence aligns with existing literature, suggesting effective diagnostic approaches.
  • The poor prognosis underscores the aggressive nature of CUP and the urgent need for improved therapeutic strategies.

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