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German pediatric reference data for quantitative transverse transmission ultrasound of finger phalanges
R Barkmann1, W Rohrschneider, M Vierling
1Medizinische Physik, Klinik für Diagnostische Radiologie, Universitätsklinikum Kiel, Germany.
Insights
Quantitative ultrasound (QUS) of finger bones provides a radiation-free method to assess bone health in children. This study established a German reference database for QUS parameters in children aged 3-17 years, crucial for identifying skeletal growth disorders.
Area of Science:
- Pediatric Orthopedics
- Biomedical Engineering
- Radiology
Background:
- Quantitative ultrasound (QUS) is valuable for assessing bone health and age-related bone loss.
- A reference database for QUS parameters in children is essential for studying skeletal growth disorders.
Purpose of the Study:
- To establish a calibrated reference database of transverse ultrasound transmission parameters in juvenile finger phalanges.
- To provide normative data for quantitative ultrasound in a German pediatric population.
Main Methods:
- Quantitative ultrasound (QUS) measurements of finger phalanges were performed on 1328 children (ages 3-17) in Germany.
- Transverse ultrasound transmission parameters, including amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT), were analyzed.
- Correlations with age, body height, and BMI were assessed, with gender-specific analyses.
Main Results:
- Significant gender-specific correlations were found between QUS parameters (AD-SoS, BTT) and age, height, and BMI (p<0.0001).
- Age and height were the strongest determinants of QUS results.
- Gender-specific differences in AD-SoS and BTT were observed at specific ages and height ranges.
Conclusions:
- The established German reference database for phalangeal QUS parameters can aid in evaluating juvenile skeletal diseases and growth disorders.
- Comparing individual QUS results with age- and height-specific reference data allows for radiation-free assessment of bone health in children.
- This approach facilitates early detection and management of pediatric skeletal conditions.
Abstract:
Quantitative ultrasound (QUS) of the finger phalanges is a useful tool in the assessment of disease- or age-related deterioration of bone. For studying the impact of juvenile diseases or growth disorders affecting the skeleton, a reference database for QUS parameters is needed. The aim of this study was to establish a calibrated reference database of parameters of transverse ultrasound transmission through juvenile finger phalanges. A total of 1328 children (650 females, 678 males; ages 3-17 years) were measured in Heidelberg and Kiel in order to establish a German reference database. Highly significant gender-specific correlations (p<0.0001) were found between the QUS parameters amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT) versus age, body height and body mass index (BMI). For AD-SoS the correlation coefficients were R2 = 0.64 against age in males and R2 = 0.73 in females, R2 = 0.60 against body height in males and R2 = 0.68 in females, and R2 = 0.19 against BMI in males and R2 = 0.23 in females. For BTT the correlation coefficients were R2 = 0.74 against age in males and R2 = 0.79 in females, R2 = 0.75 against body height in males and R2 = 0.77 in females, and R2 = 0.32 against BMI in males and R2 = 0.35 in females. Age and height were the strongest determinants of QUS results. Gender-specific differences were observed in AD-SoS (significant for ages 11-14 years and for 150-170 cm body height) and in BTT (significant for ages 7 and 11-17 years and for 160-170 cm body height). Tables of QUS parameters versus age and height can serve as a basis for the evaluation of the impact of skeletal diseases or growth disorders on phalangeal QUS. Depending on the type of disease or growth disorder, measurement results can be compared with age- or height- specific reference data. In this way a simple and radiation-free assessment of juvenile skeletal disorders using quantitative ultrasound might be possible in the future.