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Propofol effective concentration 50 and its relationship to bispectral index
M G Irwin1, T W C Hui, S E Milne
1Department of Anaesthesiology, University of Hong Kong, Room 424, K Block, Queen Mary Hospital, Pokfulam Road, Hong Kong. mgirwin@hkucc.hku.hk
Anaesthesia
|March 7, 2002
Summary
This study found that the Bispectral Index (BIS) effectively monitors anesthesia depth during propofol infusion. BIS correlates well with clinical endpoints, aiding in precise anesthetic drug delivery.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol is a widely used intravenous anesthetic agent.
- Target-controlled infusion (TCI) systems aim for precise drug delivery.
- Monitoring anesthetic depth is crucial for patient safety.
Purpose of the Study:
- To evaluate the correlation between Bispectral Index (BIS) and propofol concentrations.
- To determine the propofol concentrations for achieving specific anesthetic endpoints.
- To assess the utility of BIS during propofol-induced anesthesia.
Main Methods:
- Sixty healthy adult patients were studied.
- Anesthesia was induced using intravenous propofol via a 'Diprifusor' TCI system.
- Bispectral Index (BIS) and spectral edge frequency (SEF95) were measured alongside predicted propofol concentrations.
Main Results:
- Logistic regression identified predicted propofol concentrations for 50% and 95% patient response.
- BIS demonstrated a good correlation with clinical endpoints of unconsciousness and lack of response to noxious stimuli.
- The Diprifusor TCI system maintained consistent target propofol concentrations.
Conclusions:
- Bispectral Index (BIS) is a reliable indicator of anesthetic depth during propofol TCI.
- BIS can be a valuable tool for optimizing propofol anesthesia.
- Consistent anesthetic delivery is achievable with the Diprifusor TCI system.