Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyetherimide: a new membrane-forming polymer for biomedical applications.

B Seifert1, G Mihanetzis, T Groth

  • 1Institute of Chemistry, Department of Biomaterials, GKSS Research Center Geesthacht GmbH, Teltow, Germany. Groth@gkss.de

Artificial Organs
|March 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Introgression and Divergence in a Young Species Group.

Molecular ecology·2026
Same author

Semipermeable species boundaries create opportunities for gene flow and adaptive potential.

Molecular ecology·2023
Same author

Efficacy of quadruple treatment on different types of pre-operative anaemia: secondary analysis of a randomised controlled trial.

Anaesthesia·2020
Same author

Factors associated with having an indication for surgery in adult spinal deformity: an international european multicentre study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2018
Same author

Using an animated patient avatar to improve perception of vital sign information by anaesthesia professionals.

British journal of anaesthesia·2018
Same author

Systematic review: probiotics in the management of lower gastrointestinal symptoms - an updated evidence-based international consensus.

Alimentary pharmacology & therapeutics·2018

Polyetherimide membranes show promise for biohybrid organs, offering improved blood and tissue compatibility after surface modifications. These enhanced membranes are suitable for advanced biomedical applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Membrane Technology

Background:

  • Biohybrid organs require membranes with dual biocompatibility for blood and tissue interfaces.
  • Polyetherimide (PEI) is a potential material for these membranes, but its surface properties need optimization.

Purpose of the Study:

  • To modify polyetherimide membranes to enhance biocompatibility for both blood and tissue environments.
  • To evaluate the performance of modified PEI membranes in biohybrid organ systems.

Main Methods:

  • Flat polyetherimide membranes were fabricated using a phase inversion process.
  • Surface modifications included binding tris-(hydroxymethyl)-aminomethane, polyethylene imine, and heparin.
  • Physicochemical methods were used to confirm ligand binding.

Related Experiment Videos

  • Blood response and tissue compatibility were assessed and compared to controls.

    • Main Results:

    • Successful binding of ligands (hydroxyl groups, hydrophilic macromolecules, heparin) to the polyetherimide surface was confirmed.
    • Blood compatibility of PEI was comparable to polyacrylonitrile and improved with heparin.
    • Tissue compatibility of PEI was comparable to commercial cell culture membranes and enhanced after modification.

    Conclusions:

    • Surface-modified polyetherimide membranes exhibit favorable biocompatibility for both blood and tissue.
    • PEI is a promising material for developing membranes for biohybrid organ applications, such as liver support systems.