The effects of serotonin on feeding in the rabbit

Serotonin infused through hepatic-portal cannulae of rabbits decreased food intake in a free-feeding condition. Following a 12 hr food deprivation period similar doses of serotonin increased food intake. Other investigators have shown release of serotonin to food and related stimuli. Our results demonstrate that serotonin is not a simple "satiety hormone" but suggest that it may be importantly involved in short-term regulatory mechanisms of feeding.