Documenting regression of atherosclerosis: practical approaches in drug development

Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial.

European heart journal·2022

Advancing Beyond Failed High-density Lipoprotein Clinical Trials to Pharmacogenetic Studies of ADCY9 and Cholesterol Ester Transfer Protein Inhibition.

Journal of cardiovascular pharmacology·2021

Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

Circulation. Genomic and precision medicine·2021

Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease.

Diabetes care·2020

Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.

American heart journal·2020

Association of high-density lipoprotein particle concentration with cardiovascular risk following acute coronary syndrome: A case-cohort analysis of the dal-Outcomes trial.

American heart journal·2020

Coronary Aneurysmal and Ectatic Disease: Cath-Lab Diagnosis and Contemporary Interventional Management.

The American journal of cardiology·2026

Early Aspirin Discontinuation vs 12-Month Dual Antiplatelet Therapy after Percutaneous Coronary Intervention for Acute Coronary Syndrome: A Meta-Analysis of Randomized Trials.

The American journal of cardiology·2026

Racial and Ethnic Differences in Transcatheter Coarctation Repair among Adolescents and Adults.

The American journal of cardiology·2026

Examining the Association Between Diabetes and Cardiovascular Outcomes in South Asian Compared with White North American Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.

The American journal of cardiology·2026

Trends and Projections in Valvular Heart Disease Mortality Among Older Adults in the United States, 1999-2040.

The American journal of cardiology·2026

Early Transcatheter Edge-to-Edge Repair is Associated with Improved Mid-term Outcomes in Degenerative Mitral Regurgitation.

The American journal of cardiology·2026

Astragaloside IV Protects against PM2.5-Induced Spermatocyte Injury via the cGAS-STING/Nrf2/HMOX1 Axis.

Reproductive toxicology (Elmsford, N.Y.)·2026

Alleviation of senkyunolide A on hyperuricemia and hyperuricemia-induced renal damage in rats.

Biochemical and biophysical research communications·2026

Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model.

Biochemical and biophysical research communications·2026

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms.

European journal of medicinal chemistry·2026

Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.

Bioorganic chemistry·2026

Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insights.

Bioorganic chemistry·2026

Related Experiment Videos

Documenting regression of atherosclerosis: practical approaches in drug development

Related Concept Videos

Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial.

Advancing Beyond Failed High-density Lipoprotein Clinical Trials to Pharmacogenetic Studies of ADCY9 and Cholesterol Ester Transfer Protein Inhibition.

Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease.

Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.

Association of high-density lipoprotein particle concentration with cardiovascular risk following acute coronary syndrome: A case-cohort analysis of the dal-Outcomes trial.

Coronary Aneurysmal and Ectatic Disease: Cath-Lab Diagnosis and Contemporary Interventional Management.

Early Aspirin Discontinuation vs 12-Month Dual Antiplatelet Therapy after Percutaneous Coronary Intervention for Acute Coronary Syndrome: A Meta-Analysis of Randomized Trials.

Racial and Ethnic Differences in Transcatheter Coarctation Repair among Adolescents and Adults.

Examining the Association Between Diabetes and Cardiovascular Outcomes in South Asian Compared with White North American Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.

Trends and Projections in Valvular Heart Disease Mortality Among Older Adults in the United States, 1999-2040.

Early Transcatheter Edge-to-Edge Repair is Associated with Improved Mid-term Outcomes in Degenerative Mitral Regurgitation.

Astragaloside IV Protects against PM2.5-Induced Spermatocyte Injury via the cGAS-STING/Nrf2/HMOX1 Axis.

Alleviation of senkyunolide A on hyperuricemia and hyperuricemia-induced renal damage in rats.

Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model.

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms.

Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.

Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insights.

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Documenting regression of atherosclerosis: practical approaches in drug development

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