Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paclitaxel and its formulations.

Anil K Singla1, Alka Garg, Deepika Aggarwal

  • 1University Institute of Pharmaceutical Sciences, Panjab University, 160 014, Chandigarh, India. aksingla@mailmettoday.com

International Journal of Pharmaceutics
|March 7, 2002
PubMed
Summary

Paclitaxel (Taxol) shows promise for cancer treatment but has poor water solubility. This review explores alternative drug delivery systems to improve solubility and reduce side effects for better cancer therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immobilized bacterial cell technology for sustainable industrial wastewater treatment: a review.

3 Biotech·2026
Same author

Therapeutic plasma exchange in acute liver failure: Unravelling its efficacy and impact.

Hematology, transfusion and cell therapy·2026
Same author

Analysis of Titers of Immunoglobulin M and Immunoglobulin G ABO Antibodies in Group O Blood and Plateletphersis Donors at a Tertiary Care Hospital.

Annals of African medicine·2025
Same author

Impact of low dose of gamma irradiation on thin films of Bismuth Tri-iodide.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2024
Same author

ChaQra: a cellular unit of the Indian quantum network.

Scientific reports·2024
Same author

Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors.

Drug design, development and therapy·2024

Area of Science:

  • Oncology
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Paclitaxel (Taxol) is an effective anti-tumor agent for ovarian and breast cancers.
  • Current intravenous formulations exhibit poor water solubility and potential allergic reactions due to Cremophor EL.
  • Clinical application is limited by the lack of suitable delivery vehicles, necessitating alternative formulations.

Purpose of the Study:

  • To review various approaches for developing improved paclitaxel formulations.
  • To address the challenges of poor aqueous solubility and side effects associated with paclitaxel.

Main Methods:

  • Literature review of different paclitaxel delivery systems.
  • Discussion of various formulation strategies including cosolvents, emulsions, micelles, liposomes, nanoparticles, cyclodextrins, pastes, and implants.

Related Experiment Videos

Main Results:

  • Multiple formulation strategies have been investigated to enhance paclitaxel's aqueous solubility and therapeutic efficacy.
  • These approaches aim to overcome the limitations of conventional paclitaxel delivery.

Conclusions:

  • Development of alternative paclitaxel formulations is crucial for enhancing its clinical utility.
  • Further research into novel drug delivery systems can improve cancer treatment outcomes.