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Related Experiment Videos

Super harmonic imaging: a new imaging technique for improved contrast detection.

Ayache Bouakaz1, Sigmund Frigstad, Folkert J Ten Cate

  • 1Experimental Echocardiography, Erasmus University, Rotterdam, The Netherlands. bouakaz@tch.fgg.eur.nl

Ultrasound in Medicine & Biology
|March 7, 2002
PubMed
Summary

This study introduces a novel dual-frequency phased array transducer for ultrasound contrast imaging. It significantly enhances the contrast-to-tissue ratio (CTR) by utilizing super harmonic components, improving image clarity and diagnostic potential.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Acoustics

Background:

  • Nonlinear imaging is crucial for ultrasound contrast agents (UCA).
  • Discriminating between UCA and perfused tissue is a key challenge, often quantified by contrast-to-tissue ratio (CTR).
  • Second harmonic imaging offers improved CTR over fundamental imaging but is limited by tissue-generated harmonics.

Purpose of the Study:

  • To develop a new phased array transducer capable of utilizing higher harmonic frequencies (super harmonics) for UCA imaging.
  • To enhance the contrast-to-tissue ratio (CTR) beyond conventional second harmonic imaging.
  • To improve the discrimination between ultrasound contrast agents and biological tissues.

Main Methods:

  • Development of a novel 96-element phased array transducer with interleaved odd (2.8 MHz) and even (900 kHz) elements operating at distinct frequencies.

Related Experiment Videos

  • Separate transmission and reception modes utilizing the dual-frequency capabilities of the transducer.
  • In vitro and animal experiments to evaluate the performance of the new transducer with commercially available UCA.

    • Main Results:

    • In vitro measurements demonstrated a 40 dB increase in CTR for super harmonic components compared to conventional second harmonic imaging.
    • The observed CTR increase aligns with theoretical models for encapsulated bubbles and nonlinear propagation.
    • Animal experiments confirmed the feasibility and significant CTR improvement using the developed transducer with commercial UCA.

    Conclusions:

    • The novel dual-frequency phased array transducer effectively utilizes super harmonic components to significantly increase CTR in ultrasound contrast imaging.
    • This advancement offers superior discrimination between UCA and tissue, leading to potentially improved diagnostic accuracy.
    • The developed technology holds promise for optimizing nonlinear ultrasound imaging techniques.