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Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection
Janine T Bossé1, Håkan Janson, Brian J Sheehan
1Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Campus, W2 1PG, London, UK. j.bosse@ic.ac.uk
Microbes and Infection
|March 7, 2002
Abstract:
Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a highly contagious disease for which there is no effective vaccine. This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.