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A note on the quantitative properties of McGhee-von Hippel model
1CuraGen Corporation, 555 Long Wharf Drive, New Haven, CT 06511, USA. ykong@curagen.com
Biophysical Chemistry
|March 7, 2002
Abstract:
Exact closed-form expressions are presented for the properties of the McGhee-von Hippel model of non-specific binding of large ligands to one-dimensional homogeneous lattices. These properties include the midpoint location and the slope at the middle point of the binding isotherms (v varies with ln L plots), the location and magnitude of the maximum, as well as the location of the inflection point, in the Scatchard plots (v/L varies with v plots).