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Radiotherapy-related fatigue.

Barbara Alicja Jereczek-Fossa1, Hugo Raul Marsiglia, Roberto Orecchia

  • 1Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy. barbara.fossa@ieo.it

Critical Reviews in Oncology/Hematology
|March 7, 2002
PubMed
Summary

Radiotherapy-induced fatigue affects many patients during and after cancer treatment. Understanding its causes and effective management strategies is crucial for improving patient quality of life.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Patient Care

Background:

  • Radiotherapy-induced fatigue is a prevalent side-effect, impacting up to 80% of patients during treatment and 30% during follow-up.
  • This symptom is often underestimated, with only half of patients discussing it with physicians and limited interventions proposed.
  • The etiology, correlates, and prevalence of radiotherapy-induced fatigue remain poorly understood, varying by tumor site and treatment modality.

Purpose of the Study:

  • To explore the multifaceted nature of radiotherapy-induced fatigue.
  • To review current understanding of its causes, prevalence, and impact on quality of life.
  • To summarize findings from recent studies on interventions for managing this side-effect.

Main Methods:

  • Literature review of studies on radiotherapy-induced fatigue.

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  • Analysis of factors influencing fatigue levels, including tumor site and treatment type.
  • Examination of patient-reported outcomes and intervention effectiveness.

    • Main Results:

    • Fatigue's presentation and potential causes differ, with psychological factors implicated in breast cancer patients and neuromuscular decline in prostate cancer patients.
    • Fatigue significantly impacts overall quality of life, potentially more than pain or sexual dysfunction.
    • Promising interventions include relaxation therapy, psychotherapy, exercise, and sleep management, though optimal methods are not yet established.

    Conclusions:

    • Radiotherapy-induced fatigue is a significant and often underestimated adverse effect of cancer treatment.
    • Further methodologically rigorous research is essential to elucidate the causes and establish optimal prevention and management strategies.
    • Multimodal approaches addressing physical and psychological aspects may be key to improving patient outcomes.