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Related Experiment Videos

FGF10 maintains stem cell compartment in developing mouse incisors.

Hidemitsu Harada1, Takashi Toyono, Kuniaki Toyoshima

  • 1Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2-6-1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan. hide-h@mail.kyu-dent.ac.jp

Development (Cambridge, England)
|March 7, 2002
PubMed
Summary

Fibroblast growth factor (FGF) 10 is crucial for forming the stem cell compartment in developing mouse incisors. FGF10 acts as a survival factor, maintaining the stem cell population essential for continuous tooth growth.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Oral Biology

Background:

  • Mouse incisors are continuously growing, regenerative tissues.
  • Stem cells in the cervical loop are vital for enamel and dentin formation.
  • Mechanisms of stem cell compartment formation in incisors are poorly understood.

Purpose of the Study:

  • To investigate the role of fibroblast growth factor (FGF) 10 in mouse incisor stem cell compartment formation during tooth organogenesis.
  • To analyze incisor development in Fgf10-deficient mice and the effects of anti-FGF10 antibodies.

Main Methods:

  • Analysis of incisor development in Fgf10-null mice.
  • Organ culture of developing incisors with anti-FGF10 antibodies and recombinant FGF10 protein.
  • Examination of Fgf10 and Fgf3 expression patterns.

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Main Results:

  • Fgf10-null mice failed to form the cervical loop, essential for stem cell maintenance.
  • Absence of cervical loop formation correlated with altered Fgf10 and Fgf3 expression.
  • FGF10 deficiency in organ cultures led to limited dental epithelium growth and induced apoptosis.
  • Recombinant FGF10 protein rescued cervical loop cells from apoptosis.

Conclusions:

  • FGF10 is essential for the survival and maintenance of the stem cell population in developing mouse incisors.
  • FGF10 plays a critical role in the formation of the stem cell compartment during tooth organogenesis.