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Related Experiment Videos

[A new contrast medium (author's transl)].

H Wehling

    Der Radiologe
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A novel roentgen contrast medium using L-lysine instead of N-methyl-glucamine shows good tolerance and stable vital signs in angiographic and urologic exams. This new contrast agent offers promising clinical and roentgenological benefits.

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    Area of Science:

    • Radiology and Diagnostic Imaging
    • Medical Chemistry

    Background:

    • Traditional roentgen contrast media often utilize body-foreign bases like N-methyl-glucamine.
    • Physiologic alpha-amino acids offer a potential alternative for improved biocompatibility.

    Purpose of the Study:

    • To evaluate a new roentgen contrast medium formulated with physiologic alpha-amino acids (L-lysine, L-ornithine) as cations.
    • To assess the clinical and roentgenological performance of the lysine salt of diatrizoate acid.

    Main Methods:

    • Development of a new roentgen contrast medium using L-lysine and L-ornithine as salt-forming cations with diatrizoate acid.
    • Clinical and roentgenological evaluation of the lysine salt of diatrizoate acid in angiographic and urologic examinations.

    Main Results:

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    • The lysine salt of diatrizoate acid demonstrated favorable clinical and roentgenological outcomes.
    • Good general and local tolerance was observed during examinations.
    • Stable pulse rate and minimal blood pressure fluctuations were recorded.

    Conclusions:

    • The new roentgen contrast medium, utilizing L-lysine, exhibits excellent tolerance and physiological stability.
    • This formulation represents a potentially safer and effective alternative for diagnostic imaging procedures.