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Infectious disease experimentation involving human volunteers.

Julie Rothstein Rosenbaum1, Kent A Sepkowitz

  • 1Department of Internal Medicine, Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT, 06510, USA. Julie.rosenbaum@yale.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 7, 2002
PubMed
Summary

Healthy volunteers have been crucial in infectious disease research, enabling studies on disease transmission and treatment. Their contributions, often involving significant risks, advanced our understanding of infections like hepatitis, malaria, and respiratory illnesses.

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Area of Science:

  • Medical research
  • Infectious diseases
  • Human-subject research

Background:

  • The care of infectious disease patients relies heavily on research involving healthy volunteers.
  • Historically, volunteers have been essential for studying disease transmission, natural history, and treatment.

Purpose of the Study:

  • To review the English-language literature on the use of healthy volunteers in infectious disease research.
  • To determine the contributions of these experiments to understanding disease transmission.

Main Methods:

  • A literature review of English-language medical research.
  • Focus on studies involving hepatitis, upper respiratory infections, and malaria.

Main Results:

  • Thousands of volunteers, including soldiers and imprisoned individuals, participated in induced infection studies.
Keywords:
Biomedical and Behavioral ResearchEmpirical Approach

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  • Infection was induced via injection, nebulization, and feeding of infectious agents.
  • Volunteers faced unforeseen and unpredictable risks.

    • Conclusions:

    • Healthy volunteers have made significant contributions to infectious disease research.
    • Future research must balance participant risks with societal benefits.
    • Ethical considerations are paramount in human-subject research.