Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Are all gallium citrate preparations the same?

A D Waxman, T Kawada, W Wolf

    Radiology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Technetium-99m Sestamibi Scanning Reflects Marrow Activity in a β-Thalassemia Patient Treated with an Allogeneic Bone Marrow Transplant.

    Hematology (Amsterdam, Netherlands)·2016
    Same author

    Reevaluation of the impact of a stringent low-iodine diet on ablation rates in radioiodine treatment of thyroid carcinoma.

    Thyroid : official journal of the American Thyroid Association·2001
    Same author

    The nonimpact of thyroid stunning: remnant ablation rates in 131I-scanned and nonscanned individuals.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    Inhibitory effect of monoacylglycerol on fatty acid uptake into rat intestinal epithelial cells.

    Bioscience, biotechnology, and biochemistry·2001
    Same author

    Integrative sympathetic baroreflex regulation of arterial pressure.

    Annals of the New York Academy of Sciences·2001
    Same author

    [Incomplete resection for primary non-small cell lung cancer].

    Kyobu geka. The Japanese journal of thoracic surgery·2001

    Gallium-67 citrate from different suppliers shows distinct chemical properties affecting its use in brain imaging. These in vitro differences in radiopharmaceutical chemistry may impact clinical distribution and localization.

    Area of Science:

    • Radiopharmaceutical Chemistry
    • Nuclear Medicine
    • Analytical Chemistry

    Background:

    • Clinical brain imaging often utilizes Gallium-67 citrate.
    • Variations in radiopharmaceutical quality can impact diagnostic accuracy.
    • Previous studies indicated potential differences among 67Ga citrate preparations.

    Purpose of the Study:

    • To investigate the chemical differences between 67Ga citrate from various manufacturers.
    • To understand how these differences might affect radiopharmaceutical behavior.
    • To assess the implications for brain imaging applications.

    Main Methods:

    • Chromatographic techniques were employed to analyze 67Ga citrate.
    • Mobility of 67Ga citrate from different vendors was compared.

    Related Experiment Videos

  • In vitro experiments involved altering citrate and benzyl alcohol concentrations.

    • Main Results:

    • Significant differences in chromatographic mobility were observed between vendor A and vendors B/C.
    • Increased citrate concentration in vendor B's product dramatically altered its mobility.
    • Benzyl alcohol addition did not affect chromatographic mobility.

    Conclusions:

    • In vitro chemical variations exist in 67Ga citrate from different manufacturers.
    • These variations, particularly related to citrate content, may influence radiopharmaceutical distribution.
    • Further research is needed to elucidate the mechanisms and clinical relevance of these findings.