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Updated: Aug 14, 2026

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MRI and PET in Mouse Models of Myocardial Infarction
Published on: December 19, 2013
Myocardial mapping techniques and the evaluation of new 113mIn-labeled polymethylenephosphonates for imaging
Radiology
|December 1, 1975
Abstract:
The localization of 113mIn-ethylenediamine tetraethylenephosphonate and 113mIn-diethylenetriamine pentamethylenephosphonate in myocardial infarct induced in rabbits by coronary artery ligation was investigated. Double labeling of the same tissue with 45Ca ion was used as an index of tissue degeneration. The radioactivity ratio (40-50:1) of infarcted to normal myocardium was obtained 1.5 hours after injection and 2.5 hours after infarct. For the 45Ca-labeled phosphonate derivatives, a ratio of 7-6:1 was obtained at the same time. These agents will thus be useful for the detection and localization of acute infarct.

