[Breast cancer in women with prior malignant tumors]

Indices have been studied for a relative risk of development of subsequent metachronic breast cancer (BC) in 15627 sick female subjects presenting with different localizations of primary malignant tumours. The risk for development of BC in those women presenting with cancer of chief localizations exceeds the populational morbidity probability up to 30-fold. It is the female patients having cancer of the other mammary gland, endometrium, thyroid gland, lung, and skin who demonstrated the highest risk for development of BC. Such a polyneoplasia was recorded in 150 female subjects out of the 191 ones (78.6%). The risk for BC development in those female patients with cancer of the ovaries, cervical cancer, stomach, and melanosis cutis appeared to be insignificant. Metachronic BC in cancer patients depending on the site of the primary tumour can be a sequel of different pathogenetic mechanisms, of which hormonal-and-metabolic disturbances are the chief ones together with the genetical factor, and exposure to prior methods of antitumour chemoradiation therapy as well.