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Related Experiment Videos

[Clinical experience with icodextrin. Multicenter study].

A Guerrero1, R Montes, C Martín-Herrera

  • 1Servicio de Nefrología de los Hospitales Virgen del Rocío, Sevilla.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|March 8, 2002
PubMed
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Icodextrin use in peritoneal dialysis is safe, with rare cutaneous side effects. Long-term use did not prevent weight gain or deterioration, despite reduced glucose load.

Area of Science:

  • Nephrology
  • Internal Medicine

Background:

  • Peritoneal dialysis (PD) is a crucial renal replacement therapy.
  • Icodextrin is a glucose-sparing agent used in PD to improve fluid removal and reduce glucose absorption.
  • Understanding icodextrin's long-term effects and safety profile in diverse PD populations is essential.

Purpose of the Study:

  • To analyze the clinical experience with icodextrin in a Spanish cohort of peritoneal dialysis patients.
  • To evaluate the incidence of side effects associated with icodextrin use.
  • To assess the evolution of biochemical parameters and fluid balance during long-term icodextrin treatment.

Main Methods:

  • A retrospective analysis of 51 patients on continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using icodextrin.

Related Experiment Videos

  • Recording of side effects, serum biochemical parameters (sodium, HDL-cholesterol, glucose, etc.), and body weight at baseline and up to 18 months.
  • Analysis of drainage fluid from 12 patients to determine ultrafiltration, solute clearance, and protein losses.

    • Main Results:

    • Cutaneous side effects occurred in 7.8% of patients, with two requiring icodextrin discontinuation.
    • Serum sodium levels showed a slight decrease at 6 months (p=0.006), and HDL-cholesterol decreased significantly at 6 and 12 months.
    • Icodextrin facilitated average ultrafiltration of 296 ml and solute clearance, but did not prevent weight gain or deterioration.
    • Protein losses were observed, averaging 3.2g for urea and 1.4g for albumin.

    Conclusions:

    • Icodextrin is generally well-tolerated in peritoneal dialysis patients, with a low incidence of manageable side effects.
    • Long-term icodextrin use is associated with mild decreases in serum sodium and HDL-cholesterol.
    • While effective for ultrafiltration and solute removal, icodextrin does not negate the need for careful management of metabolic complications and nutritional status in PD patients.