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Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic
Martin Sauer1, Nancy Rydholm, John Piatkowski
1Department of Pediatrics, Bone Marrow Transplantation, University of Minnesota, Minneapolis, USA.
Pediatric Hematology and Oncology
|March 8, 2002
Abstract:
Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.