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Related Experiment Videos

The Siblings With Ischemic Stroke Study (SWISS) protocol.

James F Meschia1, Robert D Brown, Thomas G Brott

  • 1Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. meschia.james@mayo.edu

BMC Medical Genetics
|March 8, 2002
PubMed
Summary
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The Siblings With Ischemic Stroke Study (SWISS) uses genome-wide scans in families to find new genetic causes of ischemic stroke. This approach helps overcome challenges in studying stroke genetics in large human cohorts.

Area of Science:

  • Genetics
  • Neurology
  • Epidemiology

Background:

  • Family and twin studies indicate a genetic influence on ischemic stroke risk.
  • Previous candidate gene studies have had limited success in identifying novel risk genes.
  • The Siblings With Ischemic Stroke Study (SWISS) was established to address these limitations.

Purpose of the Study:

  • To identify novel genetic risk factors for ischemic stroke.
  • To perform a genome-wide scan in sibling pairs concordant or discordant for ischemic stroke.
  • To utilize linkage analysis for the discovery of stroke susceptibility genes.

Main Methods:

  • Recruitment of probands with radiographically confirmed ischemic stroke and affected siblings.
  • Centralized review of medical records for stroke diagnosis confirmation.

Related Experiment Videos

  • Validated telephone interviews to confirm stroke-free status in discordant siblings.
  • Collection of blood samples for DNA analysis and creation of lymphoblastoid cell lines.
  • Planned genome-wide scan of participants.

    • Main Results:

    • This section is not detailed in the provided abstract.
    • Further analysis is required to present specific findings.

    Conclusions:

    • Genomic studies of human stroke are complex due to phenotype heterogeneity and data acquisition challenges.
    • A multicentered design facilitates efficient assembly of well-characterized stroke pedigrees.
    • The SWISS study design avoids community consent and direct cold-calling of pedigree members.