[Contemporary treatment methods in primary breast carcinoma]

Surgery for primary breast carcinoma is the method of choice. The use of the so-called conservative (sparing) techniques greatly improves late outcomes. Thus, five-year survival in patients with early cancer stages after radical resections followed by radiation therapy was 87.6% and relapse-free survival was 80.4%. Six courses of adjuvant chemotherapy in 400 patients with Stage IIb provided 5-year overall survival in 81.3% of cases and relapse-free survival in 73.7%. Neoadjuvant chemo- and radiation therapy followed by radical mastectomy preserving both breasts and adjuvant chemo- and hormone therapy increases five-year overall and relapse-free survival up to 71.6 and 41.6%, respectively. The promises of improving therapeutical outcomes are associated with early and, in some cases, preclinical diagnosis.