Effect of vagotomy on insulin release after oral and intravenous glucose administration

In 9 non-diabetic, non-obese patients, oral and intravenous glucose tolerance tests were carried out before and after vagotomy, and the serum insulin was determined. The potentiating effect on insulin release of orally administered glucose was not abolished by total vagotomy, meaning that vagal mechanisms are not likely to play a major role in this potentiation in man.