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[Assessment of the PCNA and P53 proteins expression in the proliferative, hyperplastic and neoplastic human
W Zawiślak1, A Semczuk, R Miturski
1Oddziału Ginekologii Okregowego Szpitala Kolejowego w Lublinie.
Ginekologia Polska
|March 9, 2002
Abstract:
In the current study, PCNA and p53 proteins were immunohistochemically studied in the proliferative (n = 5), hyperplastic (n = 4) and neoplastic (n = 20) human endometrium. PCNA immunostaining was noted in 2 out of 5 (40%) proliferative, 4 out of 4 (100%) hyperplastic, and in 18 out of 20 (90%) neoplastic slides. Concomitant PCNA and p53 expression was reported in 12 out of 20 (60%) malignant tumors. All non-endometrioid neoplasms were PCNA-positive, suggested this proliferative marker is commonly expressed in the unfavorable histological types of endometrial cancer.