Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The brain and salt-sensitive hypertension.

Frans H H Leenen1, Marcel Ruzicka, Bing S Huang

  • 1Hypertension Unit, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada. fleenen@ottawaheart.ca

Current Hypertension Reports
|March 9, 2002
PubMed
Summary

High salt intake triggers hypertension in salt-sensitive rats through neural pathways. Central nervous system responses to cerebrospinal fluid sodium levels, not just kidney genetics, are key to salt-induced sympathetic hyperactivity and high blood pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central nervous system mechanisms of salt-sensitive hypertension.

Physiological reviews·2025
Same author

Hypertension Canada Statement on the Use of Cuffless Blood Pressure Monitoring Devices in Clinical Practice.

American journal of hypertension·2024
Same author

Adherence to guideline-recommended care of late-onset hypertension in females versus males: A population-based cohort study.

Journal of internal medicine·2024
Same author

Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension.

Hypertension (Dallas, Tex. : 1979)·2024
Same author

Characterizing Hypertension Specialist Care in Canada: A National Survey.

CJC open·2024
Same author

Screening for hypertension in adults: protocol for evidence reviews to inform a Canadian Task Force on Preventive Health Care guideline update.

Systematic reviews·2024

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Genetics

Background:

  • Genetically salt-sensitive rat models, including Dahl S and spontaneously hypertensive rats, exhibit pronounced hypertensive reactions when subjected to a high-salt diet.
  • Neural mechanisms are critically involved in the development of salt-induced hypertension.
  • Emerging research suggests that centrally mediated sympathetic hyperactivity is a direct cause of this hypertension.

Purpose of the Study:

  • To review the current understanding of salt-induced hypertension.
  • To explore the role of neural mechanisms, particularly central sympathetic hyperactivity, in salt-induced hypertension.
  • To propose that alterations in the genetic control of neuronal responses to cerebrospinal fluid sodium may be a primary factor in salt sensitivity.

Main Methods:

Related Experiment Videos

  • This is a review article, synthesizing existing research and data.
  • It discusses findings from studies on genetically salt-sensitive rats.
  • It focuses on the neurobiological and genetic underpinnings of salt-induced hypertension.

Main Results:

  • Salt-sensitive rats demonstrate significant hypertensive responses to high salt intake.
  • Central sympathetic hyperactivity, driven by neural mechanisms, is identified as a cause of hypertension.
  • The review posits that the genetic influence extends beyond the kidney to neuronal pathways.

Conclusions:

  • The development of salt-induced hypertension and sympathetic hyperactivity is not solely determined by renal genotype.
  • Genetic control of neuronal sensitivity to cerebrospinal fluid sodium concentration likely plays a crucial role.
  • This perspective highlights the central nervous system as a key target for understanding and managing salt-induced hypertension.